Comparison of NCV of Right and Left Limb in Right handed Male Subjects.

Background: Nerve Conduction Velocity is affected by various factors like age gender & temperature. Various studies have been done regarding development of brain and dominance of right or left side, some studies have found differences between left and right hand for nerve conduction. Our aim is to compare NCV of dominant limb to nondominant limb in right hand dominant subjects and to find out if different normal values should be considered in right and left hand. Methods: The Median and Common Peroneal Nerve (CPN) of dominant as well as Non- dominant limb were used for measuring Motor & Sensory Nerve Conduction Velocity (MNCV & SNCV) in age groups of 31-35 and 36- 40 years using Medicaid system. Results: We found p value was insignificant using unpaired t-test for MNCV & SNCV of Median and Common Peroneal Nerve of left and right side. Similarly, the MNCV & SNCV of dominant and nondominant limb for median and CPN were insignificant. Conclusion: Consideration of right or left side dominance is not necessary while measuring NCV in asymptomatic subjects and different set of normal values are not required for right and left hand.

Hypoglycemic responses to insulin in normothermic and hyperthermic young dogs.

The present study was conducted in 10 healthy young dogs in which pattern of hypoglycemia to injected insulin (0.12 U/kg I.V.) was studied at normothermic (38.5 degrees C) and hyperthermic (42.5 degrees C) body temperatures. Average maximum fall in plasma glucose concentration from the control level was 44.3% and 53.8% in normothermic and hyperthermic dogs respectively. The hypoglycemic response to injected insulin was much greater and prolonged in hyperthermic dogs. The recovery of plasma glucose to preinjection level was also very sluggish and incomplete in these dogs. The above changes in hyperthermic animals may be due to enhanced secretion of insulin, as well as an increased sensitivity to injected insulin. The slow recovery of plasma glucose to preinjection level following insulin administration in hyperthermic dogs would indicate inefficient feedback mechanisms which normally operate to raise the plasma glucose during hypoglycemia.

Effect of hyperthermia on glucose homeostasis in young dogs. An experimental study.

Hyperthermia was produced in healthy anaesthetized young dogs by keeping them in a theromostatically controlled chamber, and the effects on blood glucose concentration were studies. The blood glucose levels decreased significantly at body temperatures of 40.5 degrees C and 42.5 degrees C. The decrease was greater at the latter temperature. Intravenous glucose tolerance tests were performed to study the rates of glucose utilization during hyperthermia. The calculated fractional rates of disappearance of glucose (Kt values) were found to be significantly higher in dogs having a body temperature of 42.4 degrees C. The cause of hypoglycemia produced at high body temperature seems to be due to an elevated insulin secretion which increases the over all utilization of glucose by the peripheral tissues. The study of time course of hyperglycemic response following intravenous glucose tolerance tests performed at high body temperature further support the possibility of an increase in insulin secretion in dogs subjected to hyperthermia.